反应详情

温度

90 °C

A mixture of N-ethyl-3-fluoro-4-methyl-5-[3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indazol-6-yl]benzamide (Intermediate 21, 100 mg), 10% palladium on carbon (20 mg) and ammonium formate (50 mg) in ethanol (10 mL) was stirred at 90° C. for 1 h under nitrogen. The catalyst was removed by filtration and the filtrate was concentrated under vacuum. The product was dissolved in methanol and eluted through an SCX ion exchange cartridge. Elution with a solution of ammonia (0.88) in methanol gave the title compound as a white solid (89 mg).

1. customThe catalyst was removed by filtration
2. concentrationthe filtrate was concentrated under vacuum
3. dissolutionThe product was dissolved in methanol
4. washeluted through an SCX ion exchange cartridge
5. washElution with a solution of ammonia (0.88) in methanol