Ethyl isocyanate → HCID 178464759, compound

HRID 2246636Notes

Reaction equation

HRID 2246636 reaction equation
[CH2:1]([N:3]=[C:4]=[O:5])[CH3:2].[CH2:6]([NH:8][C:9](=[O:32])[C:10]1[CH:15]=[C:14]([C:16]2[CH:24]=[C:23]3[C:19]([C:20]([CH:25]4[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]4)=[N:21][NH:22]3)=[CH:18][CH:17]=2)[C:13]([CH3:31])=[CH:12][CH:11]=1)[CH3:7]>CN(C=O)C>[CH2:1]([NH:3][C:4]([N:28]1[CH2:29][CH2:30][CH:25]([C:20]2[C:19]3[C:23](=[CH:24][C:16]([C:14]4[CH:15]=[C:10]([C:9]([NH:8][CH2:6][CH3:7])=[O:32])[CH:11]=[CH:12][C:13]=4[CH3:31])=[CH:17][CH:18]=3)[NH:22][N:21]=2)[CH2:26][CH2:27]1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 178464758HCID 178464758, compound2×

Product 1

HCID 178464759HCID 178464759, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Ethyl isocyanate (4 μL) was added to N-ethyl-4-methyl-5-[3-(4-piperidinyl)-1H-indazol-6-yl]benzamide (Intermediate 16, 20 mg) in DMF (3 mL) at room temperature under nitrogen and the reaction mixture was stirred at room temperature for 30 min. The product was concentrated under vacuum and the residue was purified by preparative HPLC to give the title compound as a white solid (13 mg).

Workup

  1. concentrationThe product was concentrated under vacuum
  2. customthe residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-92e6d874af4b428f86a1a6e2c188f819
Source dataset
uspto-grants-2010_03
Patent number
US07687532B2

Reaction notes

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