HCID 57835837, compound → HCID 57835847, compound

HRID 2246642Notes

Reaction equation

HRID 2246642 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([C:22]2[O:23][C:24]([CH3:27])=[CH:25][N:26]=2)[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1)C1C=CC=CC=1>CCO.[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([C:22]2[O:23][C:24]([CH3:27])=[CH:25][N:26]=2)[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=1

Participants

4

Reactant 1

HCID 57835837HCID 57835837, compound

Product 1

HCID 57835847HCID 57835847, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of ethyl 3-(4-(benzyloxy)phenyl)-3-(5-methyloxazol-2-yl)propanoate (M5.3) (2.47 mmol) and Pd—C (270 mg) in EtOH was stirred under hydrogen atmosphere at room temperature for 4 hours. The Pd—C was removed by filtration through silica gel eluting with EtOH. After concentration, product M5 was obtained. MS ESI (pos.) m/e 276 (M+H).

Workup

  1. customThe Pd—C was removed by filtration through silica gel eluting with EtOH
  2. concentrationAfter concentration, product
  3. customwas obtained

Sources & evidence

ORD record
ord-9cb2728320294b9fb763cd9c05e3268c
Source dataset
uspto-grants-2010_03
Patent number
US07687526B2

Reaction notes

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