3-Nitroaniline → HCID 17982613, compound

HRID 2246809Notes

Reaction equation

[N+:1]([C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7])([O-:3])=[O:2].[Cl:11][C:12]1(Cl)[CH2:17][O:16][CH2:15][CH2:14][O:13]1>>[Cl:11][CH2:12][CH2:17][O:16][CH2:15][C:14]([NH:7][C:6]1[CH:8]=[CH:9][CH:10]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)=[O:13]

Participants

Reactant 2

HCID 74233-Nitroaniline

HCID 124243252,2-Dichloro-1,4-dioxane

Product 1

HCID 17982613HCID 17982613, compound

Conditions

Temperature: 80 °C

Procedure

A mixture of 1.12 g (8.12 mmol) of 3-nitroaniline and 1.11 g of 2-chlorodioxene (contains 6% of 2,2-dichlorodioxane) is heated at 80° C. with stirring for 24 hours, giving 2.1 g of 2-(2-chloroethoxy)-N-(3-nitrophenyl)acetamide as brownish oil. ESI 259.

Sources & evidence

ORD record: ord-7276bebf351b48c0b460821d6daf6baa
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07687624B2

Reaction notes

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