Hydrochloric Acid → HCID 68441392, compound

HRID 2246936Notes

Reaction equation

HRID 2246936 reaction equation
C(OC([N:8]1[C:13](=[O:14])[CH:12]=[C:11]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH2:10][C@H:9]1[C:23]([O:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:24])=O)(C)(C)C.Cl>O1CCOCC1>[CH2:26]([O:25][C:23]([C@@H:9]1[CH2:10][C:11]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:12][C:13](=[O:14])[NH:8]1)=[O:24])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68442404HCID 68442404, compound

Product 1

HCID 68441392HCID 68441392, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 1.8 g of (S)-4-(4-methoxy-phenyl)-6-oxo-3,6-dihydro-2H-pyridine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester in 15 ml of 1,4 dioxane are added 1.2 ml of 4N hydrochloric acid in 1,4 dioxane at room temperature. The reaction mixture is stirred for 1 hour and concentrated under reduced pressure to afford the title compound as an off white solid. Rf=0.1 (EtOAc-heptane 1:1); Rt=3.94.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-df7a4faaab93420f951250f91af1254a
Source dataset
uspto-grants-2010_03
Patent number
US07687495B2

Reaction notes

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