4-Aminotetrahydropyran → HCID 68443091, compound

HRID 2246970Notes

Reaction equation

HRID 2246970 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]2[C@@H:14]([O:15][CH2:16][C:17]3[CH:18]=[CH:19][C:20]4[O:25][CH2:24][CH2:23][N:22]([CH2:26][CH2:27][CH2:28][O:29][CH3:30])[C:21]=4[CH:31]=3)[CH2:13][N:12]([S:32]([C:35]3[CH:40]=[CH:39][C:38]([CH3:41])=[CH:37][CH:36]=3)(=[O:34])=[O:33])[C@@H:11]([CH2:42][C:43]([CH3:47])([CH3:46])[CH:44]=O)[CH2:10]2)=[CH:5][CH:4]=1.[NH2:48][CH:49]1[CH2:54][CH2:53][O:52][CH2:51][CH2:50]1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]2[C@@H:14]([O:15][CH2:16][C:17]3[CH:18]=[CH:19][C:20]4[O:25][CH2:24][CH2:23][N:22]([CH2:26][CH2:27][CH2:28][O:29][CH3:30])[C:21]=4[CH:31]=3)[CH2:13][N:12]([S:32]([C:35]3[CH:40]=[CH:39][C:38]([CH3:41])=[CH:37][CH:36]=3)(=[O:34])=[O:33])[C@@H:11]([CH2:42][C:43]([CH3:47])([CH3:46])[CH2:44][NH:48][CH:49]3[CH2:54][CH2:53][O:52][CH2:51][CH2:50]3)[CH2:10]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 86621627HCID 86621627, compound

Product 1

HCID 68443091HCID 68443091, compound

Procedure

Similar to example 43a, 430 mg of 3-[(2R,4R,5R)-4-(4-methoxy-phenyl)-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-piperidin-2-yl]-2,2-dimethyl-propionaldehyde and 79 mg of 4-aminotetrahydropyran are used to afford the title compound as a yellow oil. Rf=0.05 (EtOAc-heptane 1:1); Rt=4.65.

Sources & evidence

ORD record
ord-73f86609ff0c4937a2c6169980328a7e
Source dataset
uspto-grants-2010_03
Patent number
US07687495B2

Reaction notes

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