Dimethyl Sulfide → HCID 68698175, compound

HRID 2247004Notes

Reaction equation

HRID 2247004 reaction equation
C[O:2][C:3]1(OC)[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH2:19][C@H:18]([CH2:20][CH2:21][C:22]([NH2:24])=[O:23])[O:17][C:16]3=[O:25])=[CH:11][CH:10]=2)[CH2:5][CH:4]1[F:26].CSC.C(Cl)(=O)C>[Cl-].[Zn+2].[Cl-]>[O:2]=[C:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH2:19][C@H:18]([CH2:20][CH2:21][C:22]([NH2:24])=[O:23])[O:17][C:16]3=[O:25])=[CH:11][CH:10]=2)[CH2:5][CH:4]1[F:26]

Participants

5

Reactant 3

HCID 1068Dimethyl SulfideHCID 6367Acetyl chlorideHCID 68700839HCID 68700839, compound

Product 1

HCID 68698175HCID 68698175, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 3007855ZincchlorideCatalyst

Procedure

The compound was prepared by reacting (S)-{3-[4-(4,4-dimethoxy-3-fluoropiperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide with zinc chloride, dimethyl sulphide and acetyl chloride as per procedure described in Example E in 65% yield.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-a7d5f568b9394e5fb8987c7d8eae8f24
Source dataset
uspto-grants-2010_03
Patent number
US07687627B2

Reaction notes

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