Sodium Cyanide → HCID 68700167, compound

HRID 2247048Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([N:17]2[CH2:21][C@H:20]([CH2:22][NH:23][C:24](=[O:26])[CH3:25])[O:19][C:18]2=[O:27])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][C:11](=O)[C:10]([CH3:16])([CH3:15])[CH2:9]1.[C-:28]#[N:29].[Na+].[NH2:31][C:32]1[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=1>>[N:34]1[CH:35]=[CH:36][CH:37]=[C:32]([NH:31][C:11]2([C:28]#[N:29])[CH2:12][CH2:13][N:8]([C:7]3[CH:6]=[CH:5][C:4]([N:17]4[CH2:21][C@H:20]([CH2:22][NH:23][C:24](=[O:26])[CH3:25])[O:19][C:18]4=[O:27])=[CH:3][C:2]=3[F:1])[CH2:9][C:10]2([CH3:15])[CH3:16])[CH:33]=1

Participants

Reactant 3

HCID 8929Sodium Cyanide

HCID 100093-Aminopyridine

HCID 59754027HCID 59754027, compound

Product 1

HCID 68700167HCID 68700167, compoundYield 48%

Procedure

By using procedure as described in Example 45 and by reacting (S)-N-{3-[3-fluoro-4-(4-oxo-3,3-dimethylpiperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide with sodium cyanide and 3-aminopyridine the compound was obtained in 48% yield.

Workup

customwas obtained in 48% yield

Sources & evidence

ORD record: ord-80f45811703841a69bfaf397ebf8c03b
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07687627B2

Reaction notes

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