Formaldehyde → HCID 60133515, compound

HRID 2247064Notes

Reaction equation

HRID 2247064 reaction equation
[OH:1][C:2]1([CH2:26][OH:27])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][NH:20][C:21](=[O:23])[CH3:22])[O:16][C:15]3=[O:24])=[CH:10][C:9]=2[F:25])[CH2:4][CH2:3]1.C=O.[C:30]1(C)C=CC(S(O)(=O)=O)=CC=1>C1C=CC=CC=1>[O:1]1[C:2]2([CH2:3][CH2:4][N:5]([C:8]3[CH:13]=[CH:12][C:11]([N:14]4[CH2:18][C@H:17]([CH2:19][NH:20][C:21](=[O:23])[CH3:22])[O:16][C:15]4=[O:24])=[CH:10][C:9]=3[F:25])[CH2:6][CH2:7]2)[CH2:26][O:27][CH2:30]1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 6101p-Toluenesulfonic acidHCID 11349540HCID 11349540, compound

Product 1

HCID 60133515HCID 60133515, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The compound was prepared by reacting (S)-N-{3-[4-(4-hydroxy-4-hydroxymethyl-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (0.3 mmol), paraformaldehyde (0.3 mmol), p-toluene sulfonic acid (0.3 mmol), 4° A molecular sieves (0.5 g) in benzene (10 ml) and by purifying on silica gel column chromatography to provide title compound in 57% yield.

Workup

  1. customThe compound was prepared
  2. customby purifying on silica gel column chromatography

Sources & evidence

ORD record
ord-5d41e22dfda04578b9b9fd4ed8f1f53c
Source dataset
uspto-grants-2010_03
Patent number
US07687627B2

Reaction notes

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