Ethylene Glycol → HCID 59754073, compound

HRID 2247067Notes

Reaction equation

HRID 2247067 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][NH:20][C:21](=[O:23])[CH3:22])[O:16][C:15]3=[O:24])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH2:25](O)[CH2:26][OH:27].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[O:27]1[C:2]2([CH2:7][CH2:6][N:5]([C:8]3[CH:9]=[CH:10][C:11]([N:14]4[CH2:18][C@H:17]([CH2:19][NH:20][C:21](=[O:23])[CH3:22])[O:16][C:15]4=[O:24])=[CH:12][CH:13]=3)[CH2:4][CH2:3]2)[O:1][CH2:25][CH2:26]1

Participants

5

Reactant 3

HCID 174Ethylene GlycolHCID 6101p-Toluenesulfonic acidHCID 59754123HCID 59754123, compound

Product 1

HCID 59754073HCID 59754073, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The compound was prepared by reacting (S)-N-{3-[4-(4-oxo-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (0.5 mmol), ethylene glycol (0.5 mmol), p-toluene sulfonic acid (0.3 mmol) in toluene and by purifying on silica gel column chromatography to provide title compound in 69% yield.

Workup

  1. customThe compound was prepared
  2. customby purifying on silica gel column chromatography

Sources & evidence

ORD record
ord-0cf9eab211da4f329f69d41636b35196
Source dataset
uspto-grants-2010_03
Patent number
US07687627B2

Reaction notes

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