Sodium Carbonate → HCID 12784093, compound

HRID 224707Notes

Reaction equation

HRID 224707 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:21](=[O:22])[N:20]([CH2:23][CH3:24])[C:9]2[N:10]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:12]=[CH:13][C:8]=2[C:7]=1Cl)=[O:5])[CH3:2].[NH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[C:21](=[O:22])[N:20]([CH2:23][CH3:24])[C:9]2[N:10]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:12]=[CH:13][C:8]=2[C:7]=1[N:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 31268PyrrolidineHCID 12784117HCID 12784117, compound

Product 1

HCID 12784093HCID 12784093, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 0.7 g. (0.002 mole) of 5-chloro-8-ethyl-7,8-dihydro-7-oxo-2-phenylpyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester in ethanol was added 0.14 g. (0.002 mole) of pyrrolidine and 0.21 g. (0.002 mole) of sodium carbonate and this mixture was refluxed 3 hours. At that point, the solid inorganic material was filtered and the filtrate allowed to stand several days. Pale yellow crystals of the title compound formed which were removed by filtration--m.p. 149°-153° C.

Workup

  1. filtrationAt that point, the solid inorganic material was filtered
  2. waitto stand several days

Sources & evidence

ORD record
ord-d4c544d1cf6248d1bc5d4131e760d1eb
Source dataset
uspto-grants-1980_11
Patent number
US04233446

Reaction notes

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