Ethylenediamine → N~1~-(Pyridin-2-yl)ethane-1,2-diamine

HRID 2247257Notes

Reaction equation

[CH2:1]([NH2:4])[CH2:2][NH2:3].F[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1>>[N:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[NH:3][CH2:2][CH2:1][NH2:4]

Participants

Reactant 2

HCID 3301Ethylenediamine

HCID 97462-Fluoropyridine

Product 1

HCID 410428N~1~-(Pyridin-2-yl)ethane-1,2-diamine

Procedure

Ethylenediamine (6 g, 0.1 mol) and 2-fluoropyridine (10 g, 0.1 mol) were heated neat at 120° C. overnight. The reaction was cooled and the residue was used in next step without further purification.

Workup

temperatureThe reaction was cooled
customthe residue was used in next step without further purification

Sources & evidence

ORD record: ord-8107fb24bd39421a9d8452908907716f
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07687643B2

Reaction notes

Loading…