反应详情

4-(2-Amino-4-methyl-thiazol-5-yl)-N,N-dimethyl-benzenesulfonamide (Example 24a) (0.083 g, 0.28 mmol) and ethyl isocyanatoacetate (0.05 ml, 0.34 mmol) are stirred in dimethylformamide at 100° C. for 3 hours. The mixture is then partitioned between 1M aqueous hydrochloric acid and ethyl acetate. The organic extract is washed with brine, dried over MgSO4 and the solvent removed in vacuo. Purification by preparative HPLC affords the title compound. MH+ (TOF, MS, ES+): 441.4

1. customThe mixture is then partitioned between 1M aqueous hydrochloric acid and ethyl acetate
2. extractionThe organic extract
3. washis washed with brine
4. dry with materialdried over MgSO4
5. customthe solvent removed in vacuo
6. customPurification by preparative HPLC