1,2-Ethanediamine, N1,N1,N2-trimethyl- → HCID 86598414, compound

HRID 2247356Notes

Reaction equation

HRID 2247356 reaction equation
[CH2:1]([NH:3][C:4]([NH:6][C:7]1[S:8][C:9]([C:13]2[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[C:15](F)[CH:14]=2)=[C:10]([CH3:12])[N:11]=1)=[O:5])[CH3:2].[CH3:24][N:25]([CH3:30])[CH2:26][CH2:27][NH:28][CH3:29]>CS(C)=O>[CH3:24][N:25]([CH3:30])[CH2:26][CH2:27][N:28]([CH3:29])[C:15]1[CH:14]=[C:13]([C:9]2[S:8][C:7]([NH:6][C:4]([NH:3][CH2:1][CH3:2])=[O:5])=[N:11][C:10]=2[CH3:12])[CH:18]=[CH:17][C:16]=1[S:19]([CH3:22])(=[O:21])=[O:20]

Participants

4

Reactant 2

HCID 673381,2-Ethanediamine, N1,N1,N2-trimethyl-HCID 86598413HCID 86598413, compound

Product 1

HCID 86598414HCID 86598414, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
120 °C

Procedure

A stirred mixture of 1-Ethyl-3-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea (Example 73) (0.05 g, 0.14 mmol) and N,N,N′-Trimethylethylenediamine (0.25 ml, 2.1 mmol) in dry DMSO (0.5 ml) is heated under argon at 120° C. for 2 hours. The solvent is in vacuo removed and the product is purified by chromatography on silica eluting with ethanol-triethylamine (98:1) to give the titled compound. MH+: 440.1051

Workup

  1. customremoved
  2. customthe product is purified by chromatography on silica eluting with ethanol-triethylamine (98:1)

Sources & evidence

ORD record
ord-7e89cbf5a7334910b93a7c5b72287fef
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

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