1-(4-Chloro-3-(methylsulfonyl)phenyl)propan-2-one → 1-(3-(Methylsulfonyl)phenyl)propan-2-one

HRID 2247397Notes

Reaction equation

HRID 2247397 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[O:11])[CH3:10])=[CH:4][C:3]=1[S:12]([CH3:15])(=[O:14])=[O:13]>CO.[Pd]>[CH3:15][S:12]([C:3]1[CH:4]=[C:5]([CH2:8][C:9](=[O:11])[CH3:10])[CH:6]=[CH:7][CH:2]=1)(=[O:13])=[O:14]

Participants

4

Reactant 1

HCID 578311081-(4-Chloro-3-(methylsulfonyl)phenyl)propan-2-one

Product 1

HCID 665884811-(3-(Methylsulfonyl)phenyl)propan-2-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1-(4-chloro-3-methanesulphonyl-phenyl)-propan-2-one (5.49 g, 22.28 mmol) in methanol (250 ml) is stirred under hydrogen in the presence of 10% Pd on carbon (3 g) for 2 hours. The reaction mixture is filtered and concentrated in vacuo to yield a yellow oil of the titled compound.

Workup

  1. filtrationThe reaction mixture is filtered
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-20fabcc93d3a40bab64f586027cb1dbf
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

Loading…