Bromine → 1-Bromo-1-(3-methanesulphonyl-phenyl)-propanone

HRID 2247398Notes

Reaction equation

HRID 2247398 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH2:11][C:12](=[O:14])[CH3:13])[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3].[Br:15]Br>O1CCOCC1>[Br:15][CH:11]([C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([S:2]([CH3:1])(=[O:3])=[O:4])[CH:6]=1)[C:12](=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 24408BromineHCID 665884811-(3-(Methylsulfonyl)phenyl)propan-2-one

Product 1

HCID 858616531-Bromo-1-(3-methanesulphonyl-phenyl)-propanone

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A stirred solution of 1-(3-methanesulphonyl-phenyl)-propan-2-one (176b) (0.25 g, 1.18 mmol) in dioxane (10 ml) at 5° C. is treated with bromine (0.131 g, 0.82 mmol) added in two portions. The reaction is stirred and allowed to warm up to room temperature. The solvent is removed in vacuo to yield an orange oil of the titled compound.

Workup

  1. additionadded in two portions
  2. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-0a5f01175050466a8c1e5d5efcf254ae
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

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