Hydroxylamine → HCID 86620213, compound

HRID 2247650Notes

Reaction equation

HRID 2247650 reaction equation
[Si:1]([O:8][CH2:9][C:10]1[S:14][C:13]([C:15]#[N:16])=[CH:12][CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[NH2:17][OH:18]>>[Si:1]([O:8][CH2:9][C:10]1[S:14][C:13]([C:15](=[N:17][OH:18])[NH2:16])=[CH:12][CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 787HydroxylamineHCID 685228225-({[t-Butyl(dimethyl)silyl]oxy}methyl)thiophene-2-carbonitrile

Product 1

HCID 86620213HCID 86620213, compound

Procedure

The crude product of the title compound was synthesized by conducting the similar reaction to that mentioned in Example 1 (1d) using 5-({[t-butyl(dimethyl)silyl]oxy}methyl)thiophene-2-carbonitrile (1.3 g, 5.0 mmol) that was obtained in Example 4 (4a) and a 40% aqueous solution of hydroxylamine (0.7 ml). Subsequently, the crude product of the title compound thus obtained was purified by recrystallization from a mixed solvent of ethyl acetate and hexane to afford the title compound (1.2 g) in a yield of 81% as a white crystalline solid.

Workup

  1. customthe similar reaction to

Sources & evidence

ORD record
ord-635c0b18d1be449293d3418eb2c65432
Source dataset
uspto-grants-2010_03
Patent number
US07687491B2

Reaction notes

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