Hydroxylamine → HCID 86620222, compound

HRID 2247694Notes

Reaction equation

HRID 2247694 reaction equation
[Si:1]([O:8][CH2:9][C:10]1[S:14][C:13]([C:15]#[N:16])=[C:12]([CH3:17])[CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[NH2:18][OH:19]>>[Si:1]([O:8][CH2:9][C:10]1[S:14][C:13]([C:15](=[N:18][OH:19])[NH2:16])=[C:12]([CH3:17])[CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 787HydroxylamineHCID 685284495-({[t-Butyl(dimethyl)silyl]oxy}methyl)-3-methylthiophene-2-carbonitrile

Product 1

HCID 86620222HCID 86620222, compound

Procedure

The crude product of the title compound was synthesized by conducting the reaction similar to that mentioned in Example 1 (1d) using 5-({[t-butyl(dimethyl)silyl]oxy}methyl)-3-methylthiophene-2-carbonitrile (2.5 g, 9.2 mmol) that was obtained in Example 11 (11c) and a 40% aqueous solution of hydroxylamine (20 mL). Subsequently, the crude product of the title compound thus obtained was purified by chromatography on a silica gel column using a mixed solvent of ethyl acetate and hexane (0:10 to 5:95) as the eluent to afford the title compound (1.4 g) in a yield of 52% as a white crystalline solid.

Workup

  1. customthe reaction similar to

Sources & evidence

ORD record
ord-4fc51867599e4ca5b5b7bbc5b800f743
Source dataset
uspto-grants-2010_03
Patent number
US07687491B2

Reaction notes

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