3-Fluorophenol → 4-(3-Fluorophenoxy)benzoic acid

Participants

Reaction Steps

The title compound (2.0 g) was synthesized in a yield of 96% as a white crystalline solid by conducting the similar reaction to that mentioned in Example 10 (10e) using 4-fluorobenzaldehyde (1.5 g, 12 mmol), 3-fluorophenol (1.2 ml, 13 mmol), potassium carbonate (3.3 g, 24 mmol), 2-methyl-2-butene (4.8 ml, 45 mmol), potassium dihydrogenphosphate (3.1 g, 23 mmol), and sodium hypochlorite (2.5 g, 27 mmol).

Provenance & Evidence