3-Fluorophenol → 4-(3-Fluorophenoxy)benzoic acid

HRID 2247715Notes

Reaction equation

HRID 2247715 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[F:10][C:11]1[CH:12]=[C:13]([OH:17])[CH:14]=[CH:15][CH:16]=1.C(=O)([O-])[O-:19].[K+].[K+].CC(=CC)C.P([O-])(O)(O)=O.[K+].Cl[O-].[Na+]>>[F:10][C:11]1[CH:12]=[C:13]([CH:14]=[CH:15][CH:16]=1)[O:17][C:2]1[CH:9]=[CH:8][C:5]([C:6]([OH:19])=[O:7])=[CH:4][CH:3]=1

Participants

7

Reactant 6

HCID 97433-FluorophenolHCID 105532-Methyl-2-buteneHCID 11430Potassium CarbonateHCID 680234-FluorobenzaldehydeHCID 516951Monobasic potassium phosphateHCID 23665760Sodium Hypochlorite

Product 1

HCID 225734424-(3-Fluorophenoxy)benzoic acidYield 96%

Procedure

The title compound (2.0 g) was synthesized in a yield of 96% as a white crystalline solid by conducting the similar reaction to that mentioned in Example 10 (10e) using 4-fluorobenzaldehyde (1.5 g, 12 mmol), 3-fluorophenol (1.2 ml, 13 mmol), potassium carbonate (3.3 g, 24 mmol), 2-methyl-2-butene (4.8 ml, 45 mmol), potassium dihydrogenphosphate (3.1 g, 23 mmol), and sodium hypochlorite (2.5 g, 27 mmol).

Workup

  1. customthe similar reaction to

Sources & evidence

ORD record
ord-69fd330d50b04cb7a38b4e28714a7d38
Source dataset
uspto-grants-2010_03
Patent number
US07687491B2

Reaction notes

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