Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2247722Generated: November 1, 2026

Acetic Acid → HCID 11978157, compound

https://huagongshe.com/reaction/2247722

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantLithium hydroxide, monohydrateHCID 168937—
ReactantHCID 68523365HCID 68523365—
ProductHCID 11978157HCID 1197815739.7%

Reaction Steps

The title compound (77 mg) was synthesized in a yield of 38% as a white crystalline solid by conducting the reaction similar to that mentioned in Example 2 (2e) using methyl 1-[(5-{5-[4-(2,3-difluorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-4 ethyl-2-thienyl)methyl]azetidine-3-carboxylate (0.20 g, 0.39 mmol) that was obtained in Example 18 (18c), lithium hydroxide monohydrate (36 mg, 0.86 mmol), and acetic acid (47 μL, 0.86 mmol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07687491B2
Source datasetuspto-grants-2010_03
ORD IDord-5aa1f74ac40a4baf899ef36e88d85753
Source noteuspto-grants-2010_03