Acetic Acid → HCID 11978157, compound

HRID 2247722Notes

Reaction equation

HRID 2247722 reaction equation
[F:1][C:2]1[C:35]([F:36])=[CH:34][CH:33]=[CH:32][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][N:14]=[C:13]([C:16]3[S:20][C:19]([CH2:21][N:22]4[CH2:25][CH:24]([C:26]([O:28]C)=[O:27])[CH2:23]4)=[CH:18][C:17]=3[CH2:30][CH3:31])[N:12]=2)=[CH:7][CH:6]=1.O.[OH-].[Li+].C(O)(=O)C>>[F:1][C:2]1[C:35]([F:36])=[CH:34][CH:33]=[CH:32][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][N:14]=[C:13]([C:16]3[S:20][C:19]([CH2:21][N:22]4[CH2:25][CH:24]([C:26]([OH:28])=[O:27])[CH2:23]4)=[CH:18][C:17]=3[CH2:30][CH3:31])[N:12]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 168937Lithium hydroxide, monohydrateHCID 68523365HCID 68523365, compound

Product 1

HCID 11978157HCID 11978157, compoundYield 39.7%

Procedure

The title compound (77 mg) was synthesized in a yield of 38% as a white crystalline solid by conducting the reaction similar to that mentioned in Example 2 (2e) using methyl 1-[(5-{5-[4-(2,3-difluorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-4 ethyl-2-thienyl)methyl]azetidine-3-carboxylate (0.20 g, 0.39 mmol) that was obtained in Example 18 (18c), lithium hydroxide monohydrate (36 mg, 0.86 mmol), and acetic acid (47 μL, 0.86 mmol).

Workup

  1. customthe reaction similar to

Sources & evidence

ORD record
ord-5aa1f74ac40a4baf899ef36e88d85753
Source dataset
uspto-grants-2010_03
Patent number
US07687491B2

Reaction notes

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