3-Fluorophenol → HCID 28605150, compound

HRID 2247727Notes

Reaction equation

HRID 2247727 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1F)[CH:5]=[O:6].[F:11][C:12]1[CH:13]=[C:14]([OH:18])[CH:15]=[CH:16][CH:17]=1.C(=O)([O-])[O-:20].[K+].[K+].CC(=CC)C.P([O-])(O)(O)=O.[K+].Cl[O-].[Na+]>>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:18][C:14]1[CH:15]=[CH:16][CH:17]=[C:12]([F:11])[CH:13]=1)[C:5]([OH:6])=[O:20]

Participants

7

Reactant 6

HCID 97433-FluorophenolHCID 105532-Methyl-2-buteneHCID 11430Potassium CarbonateHCID 516951Monobasic potassium phosphateHCID 5880883,4-DifluorobenzaldehydeHCID 23665760Sodium Hypochlorite

Product 1

HCID 28605150HCID 28605150, compoundYield 84%

Procedure

The title compound (2.0 g) was synthesized in a yield of 84% as a yellowish white crystalline solid by conducting the similar reaction to that mentioned in Example 10 (10e) using 3,4-difluorobenzaldehyde (1.4 g, 10 mmol), 3-fluorophenol (1.6 g, 14 mmol), potassium carbonate (3.5 g, 25 mmol), 2-methyl-2-butene (5.1 ml, 48 mmol), potassium dihydrogenphosphate (3.3 g, 24 mmol), and sodium hypochlorite (2.6 g, 29 mmol).

Workup

  1. customthe similar reaction to

Sources & evidence

ORD record
ord-49de08f7973649918645b373ac5094c5
Source dataset
uspto-grants-2010_03
Patent number
US07687491B2

Reaction notes

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