Hydroxylamine → HCID 86620224, compound

HRID 2247737Notes

Reaction equation

HRID 2247737 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([C:16]#[N:17])[S:6][C:7]=1[CH2:8][O:9][CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][O:11]1)[CH3:2].[NH2:18][OH:19]>>[CH2:1]([C:3]1[CH:4]=[C:5]([C:16](=[N:18][OH:19])[NH2:17])[S:6][C:7]=1[CH2:8][O:9][CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][O:11]1)[CH3:2]

Participants

3

Reactant 2

HCID 787HydroxylamineHCID 68522065HCID 68522065, compound

Product 1

HCID 86620224HCID 86620224, compound

Procedure

The crude product of the title compound was synthesized by conducting the reaction similar to that mentioned in Example 1 (1d) using 4-ethyl-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]thiophene-2-carbonitrile (0.86 g, 3.4 mmol) that was obtained in Example 22 (22c) and a 50% aqueous solution of hydroxylamine (0.5 mL). Subsequently, the crude product of the title compound thus obtained was purified by chromatography on a silica gel column using a mixed solvent of ethyl acetate and hexane (1:3 to 5:5) as the eluent to afford the title compound (0.96 g) in a yield of 98% as a colourless oily product.

Workup

  1. customthe reaction similar to

Sources & evidence

ORD record
ord-4356a73c6b794964a64403eee09c114b
Source dataset
uspto-grants-2010_03
Patent number
US07687491B2

Reaction notes

Loading…