Acetic Acid → HCID 24986921, compound

HRID 2247741Notes

Reaction equation

HRID 2247741 reaction equation
[CH2:1]([C:3]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[CH:15][CH:14]=3)[O:10][N:9]=2)[S:5][C:4]=1[CH2:26][N:27]1[CH2:30][CH:29]([C:31]([O:33]C)=[O:32])[CH2:28]1)[CH3:2].[OH-].[Na+].C(O)(=O)C>>[CH2:1]([C:3]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([C:13]3[CH:14]=[CH:15][C:16]([O:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[CH:17][CH:18]=3)[O:10][N:9]=2)[S:5][C:4]=1[CH2:26][N:27]1[CH2:30][CH:29]([C:31]([OH:33])=[O:32])[CH2:28]1)[CH3:2]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 68526846HCID 68526846, compound

Product 1

HCID 24986921HCID 24986921, compoundYield 96.3%

Procedure

The title compound (0.16 g) was synthesized in a yield of 95% as a white crystalline solid by conducting the reaction similar to that mentioned in Example 3 (3e) using methyl 1-({3-ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl}methyl)azetidine-3-carboxylate (0.17 g, 0.36 mmol) that was obtained in Example 22 (22g), a 1 N aqueous solution of sodium hydroxide (1.1 mL, 1.1 mmol), and acetic acid (62 μL, 1.1 mmol).

Workup

  1. customthe reaction similar to

Sources & evidence

ORD record
ord-172e864643164e6bb9e3acbf059f1832
Source dataset
uspto-grants-2010_03
Patent number
US07687491B2

Reaction notes

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