Sodium Hydroxide → 1-({6-Ethyl-5-[5-(4-isobutyl-3-methylphenyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}methyl)azetidine-3-carboxylic acid

HRID 2247778Notes

Reaction equation

HRID 2247778 reaction equation
[CH2:1]([C:3]1[N:8]=[C:7]([CH2:9][N:10]2[CH2:13][CH:12]([C:14]([O:16]C)=[O:15])[CH2:11]2)[CH:6]=[CH:5][C:4]=1[C:18]1[N:22]=[C:21]([C:23]2[CH:28]=[CH:27][C:26]([CH2:29][CH:30]([CH3:32])[CH3:31])=[C:25]([CH3:33])[CH:24]=2)[O:20][N:19]=1)[CH3:2].[OH-].[Na+]>>[CH2:1]([C:3]1[N:8]=[C:7]([CH2:9][N:10]2[CH2:13][CH:12]([C:14]([OH:16])=[O:15])[CH2:11]2)[CH:6]=[CH:5][C:4]=1[C:18]1[N:22]=[C:21]([C:23]2[CH:28]=[CH:27][C:26]([CH2:29][CH:30]([CH3:32])[CH3:31])=[C:25]([CH3:33])[CH:24]=2)[O:20][N:19]=1)[CH3:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68521940Methyl 1-({6-ethyl-5-[5-(4-isobutyl-3-methylphenyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}methyl)azetidine-3-carboxylate

Product 1

HCID 119496191-({6-Ethyl-5-[5-(4-isobutyl-3-methylphenyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}methyl)azetidine-3-carboxylic acidYield 82%

Procedure

The title compound (0.10 g) was synthesized in a yield of 82% as a white crystalline solid by conducting the reaction similar to that mentioned in Example 3 (3e) using methyl 1-({6-ethyl-5-[5-(4-isobutyl-3-methylphenyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}methyl)azetidine-3-carboxylate (0.13 g, 0.29 mmol) that was obtained in Example 29 (29b) and a 1 N aqueous solution of sodium hydroxide (0.87 mL, 0.87 mmol).

Workup

  1. customthe reaction similar to

Sources & evidence

ORD record
ord-a1203e7697fc498fa18e1054d709310a
Source dataset
uspto-grants-2010_03
Patent number
US07687491B2

Reaction notes

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