反应详情

温度

60 °C

A mixture containing 0.71 g (5 mmol) of 6-methyl-2-thiouracil, 0.76 g (5 mmol) of 2-dimethylaminobenzyl alcohol (J. Chem. Soc. 1954, 4127) and 5 ml of concentrated hydrochloric acid is stirred at 60° C. for 3 hours, then cooled and made alkaline by adding 5N sodium hydroxide solution under cooling by ice. The mixture is extracted 3 times with 20 ml of chloroform each. After combining the organic phase is washed with sodium carbonate solution and then with saturated sodium chloride solution, dried over anhydrous magnesium sulfate and evaporated. The residue is twice recrystallized from ethyl acetate to yield 0.59 g (43%) of the title compound, m.p.: 151°-153° C.

1. temperaturecooled
2. temperatureunder cooling by ice
3. extractionThe mixture is extracted 3 times with 20 ml of chloroform each
4. washis washed with sodium carbonate solution
5. dry with materialwith saturated sodium chloride solution, dried over anhydrous magnesium sulfate
6. customevaporated
7. customThe residue is twice recrystallized from ethyl acetate