Hydrochloric Acid → HCID 19815962, compound

HRID 2247870Notes

Reaction equation

HRID 2247870 reaction equation
[C:1]([C:3]1[C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[CH:16]=2)=[CH:5][C:6]([C:10]([O:12]CC)=[O:11])=[N:7][C:8]=1[CH3:9])#[N:2].[OH-].[Na+].Cl>C(O)C.O>[C:1]([C:3]1[C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[CH:16]=2)=[CH:5][C:6]([C:10]([OH:12])=[O:11])=[N:7][C:8]=1[CH3:9])#[N:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19815927HCID 19815927, compound

Product 1

HCID 19815962HCID 19815962, compoundYield 95.9%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of ethyl 5-cyano-6-methyl-4-(3-nitrophenyl)-2-pyridinecarboxylate (2.75 g) in ethanol (30 ml) was added a solution of sodium hydroxide (0.37 g) in water (6 ml). After the mixture was stirred at ambient temperature for 1.5 hours, the reaction mixture was adjusted to pH 2 with 6N hydrochloric acid. The resulting precipitates were filtered off, washed with water, and dried to give 5-cyano-6-methyl-4-(3-nitrophenyl)-2-pyridinecarboxylic acid (2.4 g).

Workup

  1. customThe resulting precipitates
  2. filtrationwere filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-0736372a671643fcb0f7c10fda3f1746
Source dataset
uspto-grants-1991_08
Patent number
US05037824

Reaction notes

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