2-Morpholinoethylamine → HCID 19815985, compound

HRID 2247877Notes

Reaction equation

HRID 2247877 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:13]([CH3:20])[N:12]=[C:11]([C:21]([OH:23])=O)[CH:10]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2].[O:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][NH2:32])[CH2:26][CH2:25]1.[C:33]([OH:40])(=[O:39])/[CH:34]=[CH:35]/[C:36]([OH:38])=[O:37]>C(O)C>[C:33]([OH:40])(=[O:39])/[CH:34]=[CH:35]/[C:36]([OH:38])=[O:37].[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]([C:21](=[O:23])[NH:32][CH2:31][CH2:30][N:27]3[CH2:28][CH2:29][O:24][CH2:25][CH2:26]3)[N:12]=[C:13]([CH3:20])[C:14]=2[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:6]=[CH:7][CH:8]=1)#[N:2]

Participants

5

Reactant 3

HCID 4082852-MorpholinoethylamineHCID 444972Fumaric AcidHCID 19815947HCID 19815947, compound

Product 1

HCID 19815985HCID 19815985, compoundYield 52.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 4-(3-cyanophenyl)-2-methyl-6-(2-morpholinoethylcarbamoyl)-3-pyridinecarboxylate, which was obtained according to a similar manner to that of Example 18 from 4-(3-cyanophenyl)-5-ethoxycarbonyl-6-methyl-2-pyridinecarboxylic acid (0.93 g) and 2-morpholinoethylamine (0.39 g), was treated with a solution of fumaric acid (0.54 g) in ethanol (11 ml) to give ethyl 4-(3-cyanophenyl)-2-methyl-6-(2-morpholinoethylcarbamoyl)-3-pyridinecarboxylate fumarate (0.84 g).

Sources & evidence

ORD record
ord-4239e1a2d80a48ddbc50549d3d2af918
Source dataset
uspto-grants-1991_08
Patent number
US05037824

Reaction notes

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