Acetic Acid → HCID 54412810, compound

HRID 2247910Notes

Reaction equation

HRID 2247910 reaction equation
C[O:2][CH:3](OC)[C:4]1[CH:9]=[C:8]([CH:10]([N:17]2[CH:21]=[CH:20][N:19]=[CH:18]2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[NH:22][C:23](=[O:25])[CH3:24].C(O)(=O)C>O>[CH:3]([C:4]1[CH:9]=[C:8]([CH:10]([N:17]2[CH:21]=[CH:20][N:19]=[CH:18]2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[NH:22][C:23](=[O:25])[CH3:24])=[O:2]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 53870111HCID 53870111, compound

Product 1

HCID 54412810HCID 54412810, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 2.5 parts of intermediate 67, namely N-[2-(dimethoxymethyl)-4-[(1H-imidazol-1-yl)phenylmethyl]phenyl]acetamide, 52.5 parts of acetic acid and 10 parts of water was stirred for 1/2 hour at reflux temperature. The reaction mixture was evaporated and the residue was co-evaporated with methylbenzene, yielding 2.2 parts (100%) of N-[2-formyl-4-[(1H-imidazol-1-yl)phenylmethyl]phenyl]acetamide (interm. 68).

Workup

  1. temperatureat reflux temperature
  2. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-0e383bb149d64602a318ed8e271fa5f8
Source dataset
uspto-grants-1991_08
Patent number
US05037829

Reaction notes

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