HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → Ethyl 2-(2-chloro-4,5-difluorobenzoyl)-3-ethoxyacrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 2-Chloro-4,5-difluoro-alpha-oxobenzenepropanoic acid ethyl ester | HCID 53662473 | — |
| Product | Ethyl 2-(2-chloro-4,5-difluorobenzoyl)-3-ethoxyacrylate | HCID 54163438 | — |
Reaction Steps
2-Chloro-4,5-difluoro-α-oxo-benzenepropanoic acid ethyl ester (20 g, 76 mmol), triethylorthoformate (17.0 g, 115 mmol) and acetic anhydride (19.5 g, 191 mmol) were combined and heated to reflux for 3 hours. Excess solvent was removed in vacuo to provide the crude title product, which was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05037834 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-10556f09c0af49d788866943a334d7bd |
| Source note | uspto-grants-1991_08 |