反应详情

2-Chloro-4,5-difluoro-α-oxo-benzenepropanoic acid ethyl ester (20 g, 76 mmol), triethylorthoformate (17.0 g, 115 mmol) and acetic anhydride (19.5 g, 191 mmol) were combined and heated to reflux for 3 hours. Excess solvent was removed in vacuo to provide the crude title product, which was used without purification.

1. temperatureheated
2. temperatureto reflux for 3 hours
3. customExcess solvent was removed in vacuo