化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 2-(2-(2-Aminothiazol-4-yl)ethyl)isoindoline-1,3-dione hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Thiourea | HCID 2723790 | — |
| 反応物 | 2-(4-Bromo-3-oxobutyl)-1H-isoindole-1,3(2H)-dione | HCID 3759744 | — |
| 溶媒 | 1-Propanol | HCID 1031 | — |
| 生成物 | 2-(2-(2-Aminothiazol-4-yl)ethyl)isoindoline-1,3-dione hydrochloride | HCID 44118301 | — |
反応手順
1-Bromo-4-N-phthalimido-2-butanone (50.0 g, 0.169 mol) and thiourea (25.71 g, 0.338 mol) were mixed with n-propanol (1000 ml) and concentrated hydrochloric acid (100 ml), and the reaction mixture was heated to reflux for 1.5 hour. After cooling, the precipitate was filtered and washed with n-propanol and ether. After air drying, the title product was obtained as a fluffy white solid (37.51 g, 0.121 mol, 72% yield), m.p. 230°-240° (decomp.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05037834 |
| 出典データセット | uspto-grants-1991_08 |
| ORD ID | ord-799a2794326549a88fe2587ce8766e2f |
| 出典メモ | uspto-grants-1991_08 |