Ammonia → HCID 178511445, compound

HRID 2248032Notes

Reaction equation

HRID 2248032 reaction equation
Cl[CH2:2][C:3]([NH:5][C@H:6]1[CH2:11][CH2:10][C@H:9]([OH:12])[CH2:8][CH2:7]1)=[O:4].[NH3:13]>CO>[NH2:13][CH2:2][C:3]([NH:5][C@H:6]1[CH2:11][CH2:10][C@H:9]([OH:12])[CH2:8][CH2:7]1)=[O:4]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 178520813HCID 178520813, compound

Product 1

HCID 178511445HCID 178511445, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

11.5 g. (0.06 mole) trans-2-chloro-N-(4-hydroxycyclohexyl)-acetamide are dissolved in 100 ml. methanol and shaken with 200 ml. liquid ammonia for 20 hours at 50° C. in an autoclave. After concentration of the solvent, suction filtration is carried out. There are obtained 9.7 g. of the title compound, i.e. 94% of theory; m.p. 110°-114° C.

Workup

  1. filtrationAfter concentration of the solvent, suction filtration
  2. customThere are obtained 9.7 g

Sources & evidence

ORD record
ord-15422738a9df4540a755d194f5cdd57a
Source dataset
uspto-grants-1991_08
Patent number
US05037849

Reaction notes

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