Triethylamine → Daunorubicin

Participants

Reaction Steps

To a solution of 0.31 g of polymer precursor (9) (containing 1.35×10-4 mol of ONp groups) in 1.2 ml DMSO was added 0.028 g (5.1×10-5 mol) of daunomycin hydrochloride in 0.1 ml DMSO and 0.0052 g (5×10-5 mol) of triethylamine. The reaction mixture was stirred at room temperature for 60 minutes and then poured into 400 ml of acetone: ether (3:1) mixture to precipitate the polymer. The polymer contained 2.5 mol % of side-chains terminating in daunomycin and 4.3 mol % of side-chains terminating in unreacted ONp groups.

Provenance & Evidence