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HRID2248035

反应详情

EQUATION

反应方程式

HRID 2248035 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1.Cl
HCID62770

Daunomycin hydrochloride

C27H30ClNO10

结构：CC(C)=O.CCOCC
HCID21584533

Acetone diethylether

C7H16O2

PRODUCTS

生成物

1
结构：COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1
HCID30323

Daunorubicin

C27H29NO10

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

2 次

PROCEDURE

实验过程

To a solution of 0.31 g of polymer precursor (9) (containing 1.35×10-4 mol of ONp groups) in 1.2 ml DMSO was added 0.028 g (5.1×10-5 mol) of daunomycin hydrochloride in 0.1 ml DMSO and 0.0052 g (5×10-5 mol) of triethylamine. The reaction mixture was stirred at room temperature for 60 minutes and then poured into 400 ml of acetone: ether (3:1) mixture to precipitate the polymer. The polymer contained 2.5 mol % of side-chains terminating in daunomycin and 4.3 mol % of side-chains terminating in unreacted ONp groups.

WORKUP

后处理

  1. customto precipitate the polymer
  2. customterminating in daunomycin
  3. custom4.3 mol % of side-chains terminating in unreacted ONp groups