Trifluoroacetic acid → HCID 86744971, compound

HRID 2248065Notes

Reaction equation

HRID 2248065 reaction equation
[CH3:1][O:2][C:3](=[O:20])[CH2:4][NH:5][C:6](=[O:19])[C@H:7]([CH:16]([CH3:18])[CH3:17])[NH:8]C(OC(C)(C)C)=O.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[CH3:1][O:2][C:3](=[O:20])[CH2:4][NH:5][C:6](=[O:19])[C@H:7]([CH:16]([CH3:17])[CH3:18])[NH2:8]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 14235550N-[(1,1-Dimethylethoxy)carbonyl]-L-valylglycine methyl ester

Product 1

HCID 86744971HCID 86744971, compound

Procedure

t-butyloxycarbonyl-L-valyl-glycine methyl ester (1.44 g, 5 mmol) was dissolved in trifluoroacetic acid (5 ml), and the mixture was left at room temperature for 1 hour. The solution was evaporated to dryness in vacuo and the residue triturated with dry ether.

Workup

  1. customThe solution was evaporated to dryness in vacuo
  2. customthe residue triturated with dry ether

Sources & evidence

ORD record
ord-79272b99fddf470bb0548622df5394de
Source dataset
uspto-grants-1991_08
Patent number
US05037957

Reaction notes

Loading…