Ammonia → HCID 178508172, compound

HRID 2248100Notes

Reaction equation

HRID 2248100 reaction equation
Cl[C:2]1[C:11]2[N:12]=[CH:13][NH:14][C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[NH3:15]>CO>[NH:14]1[C:10]2[C:9]3[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=3[N:3]=[C:2]([NH2:15])[C:11]=2[N:12]=[CH:13]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 178478309HCID 178478309, compound

Product 1

HCID 178508172HCID 178508172, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using the method of Example 18, the product of Example 30, 0.2g (0.0010 mole) of 4-chloro-1H-imidazo[4,5-c]quinoline was aminated at 175 ° C. in 12% ammonia in methanol to provide 1H-imidazo[4,5-c]quinolin-4-amine. The structure was verified by comparison of infrared and nuclear magnetic resonance spectra of the product with spectra of the product from Example 32 below.

Sources & evidence

ORD record
ord-faadb7def1024467910c1dcdfd3095b3
Source dataset
uspto-grants-1991_08
Patent number
US05037986

Reaction notes

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