Water → 3-[4-[1-(4-Fluorophenyl)-4-piperazinyl]butyl]-1,4-dioxothiazolidine

HRID 2248208Notes

Reaction equation

HRID 2248208 reaction equation
[OH2:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]3[C:23](=[O:24])[CH2:22][S:21][CH2:20]3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1>C1COCC1>[F:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]3[C:23](=[O:24])[CH2:22][S:21](=[O:1])[CH2:20]3)[CH2:13][CH2:14]2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 962WaterHCID 107593943-[4-[1-(4-Fluorophenyl)-4-piperazinyl]butyl]-4-thiazolidinone

Product 1

HCID 148561683-[4-[1-(4-Fluorophenyl)-4-piperazinyl]butyl]-1,4-dioxothiazolidine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A second run using NaIO4 (1.41 g), H2O (13 ml), 1 (2.02 g) and THF (20 ml) was conducted in a similar manner yielding 0.910 g of product.

Sources & evidence

ORD record
ord-c4a178cbfeff4ac59f2f1c6aba753b9c
Source dataset
uspto-grants-1991_08
Patent number
US05037984

Reaction notes

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