1,4,5,6-Tetrahydropyridazine → HCID 19995641, compound

HRID 2248255Notes

Reaction equation

HRID 2248255 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]=[N:2]1.[F:7][C:8]1[C:21]([N:22]=[C:23]=[S:24])=[CH:20][C:11]2[CH:12]([CH2:17][C:18]#[CH:19])[C:13](=[O:16])[NH:14][O:15][C:10]=2[CH:9]=1>C1C=CC=CC=1>[F:7][C:8]1[C:21]([NH:22][C:23]([N:2]2[CH2:3][CH2:4][CH2:5][CH:6]=[N:1]2)=[S:24])=[CH:20][C:11]2[CH:12]([CH2:17][C:18]#[CH:19])[C:13](=[O:16])[NH:14][O:15][C:10]=2[CH:9]=1

Participants

4

Reactant 2

HCID 5583411,4,5,6-TetrahydropyridazineHCID 19995649HCID 19995649, compound

Product 1

HCID 19995641HCID 19995641, compoundYield 28.8%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

0.32 g of 1,4,5,6-tetrahydropyridazine was dissolved in 20 ml of benzene, and 1.00 g of 7-fluoro-4-propargyl-2H-benzoxazin-3(4H)-one-6-ylisothiocyanate was added thereto. The mixture was stirred at room temperature for 3 hours. After the reaction, benzene was distilled off to obtain a crude product. This crude product was purified by silica gel column chromatography (developing solvent: chloroform) to obtain 0.38 g of the above-identified compound as yellow crystals.

Workup

  1. distillationwas distilled off
  2. customto obtain a crude product
  3. customThis crude product was purified by silica gel column chromatography (developing solvent: chloroform)

Sources & evidence

ORD record
ord-29614c48915e4be1869fac56d703ac7b
Source dataset
uspto-grants-1991_08
Patent number
US05039331

Reaction notes

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