1,4,5,6-Tetrahydropyridazine → HCID 19995641, compound

Participants

Reaction Steps

0.32 g of 1,4,5,6-tetrahydropyridazine was dissolved in 20 ml of benzene, and 1.00 g of 7-fluoro-4-propargyl-2H-benzoxazin-3(4H)-one-6-ylisothiocyanate was added thereto. The mixture was stirred at room temperature for 3 hours. After the reaction, benzene was distilled off to obtain a crude product. This crude product was purified by silica gel column chromatography (developing solvent: chloroform) to obtain 0.38 g of the above-identified compound as yellow crystals.

Provenance & Evidence