Thiophosgene → HCID 14624888, compound

HRID 2248257Notes

Reaction equation

HRID 2248257 reaction equation
[Cl:1][C:2]1[C:8]([SH:9])=[CH:7][C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.[C:11](Cl)(Cl)=[S:12]>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:8]([SH:9])=[CH:7][C:5]([N:6]=[C:11]=[S:12])=[C:4]([F:10])[CH:3]=1

Participants

4

Reactant 2

HCID 10040ThiophosgeneHCID 11019406Benzenethiol, 5-amino-2-chloro-4-fluoro-

Product 1

HCID 14624888HCID 14624888, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2.00 g of 4-chloro-2-fluoro-5-mercaptoaniline was dissolved in chloroform, and 1.12 ml of thiophosgene was dropwise added at 0° C. After the dropwise addition, the temperature was raised to room temperature and then, the mixture was refluxed. After refluxing for six hours, chloroform was distilled off to obtain 2.47 g of the above-identified compound as brown oil.

Workup

  1. additionAfter the dropwise addition
  2. temperaturethe mixture was refluxed
  3. temperatureAfter refluxing for six hours
  4. distillationchloroform was distilled off

Sources & evidence

ORD record
ord-bff620aab3b4469c86c0e4fafc68b8e4
Source dataset
uspto-grants-1991_08
Patent number
US05039331

Reaction notes

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