3,4-dihydro-2H-pyran → HCID 14624889, compound

HRID 2248258Notes

Reaction equation

HRID 2248258 reaction equation
[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:9]=[C:10]=[S:11])=[C:4]([F:12])[CH:3]=1.[O:13]1[CH:18]=[CH:17][CH2:16][CH2:15][CH2:14]1>ClCCl>[Cl:1][C:2]1[C:7]([O:8][CH:14]2[CH2:15][CH2:16][CH2:17][CH2:18][O:13]2)=[CH:6][C:5]([N:9]=[C:10]=[S:11])=[C:4]([F:12])[CH:3]=1

Participants

4

Reactant 2

HCID 80803,4-dihydro-2H-pyranHCID 14624890HCID 14624890, compound

Product 1

HCID 14624889HCID 14624889, compoundYield 80.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A dichloromethane solution containing 0.10 g of 4-chloro-2-fluoro-5-hydroxyphenylisothiocynate and 0.04 g of 2,3-dihydropyran, was stirred at room temperature for 5 hours. Then, dichloromethane was distilled off, and the residue was washed with diisopropyl ether to obtain 0.11 g of the above-identified compound as white crystals.

Workup

  1. distillationThen, dichloromethane was distilled off
  2. washthe residue was washed with diisopropyl ether

Sources & evidence

ORD record
ord-3adce5988d4c4ad9b7c43a0b7507c69f
Source dataset
uspto-grants-1991_08
Patent number
US05039331

Reaction notes

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