Isopropanol → HCID 178484949, compound

HRID 2248273Notes

Reaction equation

HRID 2248273 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][C:5]1[NH:9][C:8]2[CH:10]=[CH:11][C:12]([C:14]3[CH:15]([CH3:21])[CH2:16][C:17](=[O:20])[NH:18][N:19]=3)=[CH:13][C:7]=2[N:6]=1.[CH:22]([OH:25])([CH3:24])C>>[C:22]([NH:9][C:5]([NH:1][CH2:2][CH2:3][CH2:4][C:5]1[NH:9][C:8]2[CH:10]=[CH:11][C:12]([C:14]3[CH:15]([CH3:21])[CH2:16][C:17](=[O:20])[NH:18][N:19]=3)=[CH:13][C:7]=2[N:6]=1)=[N:6][CH3:7])(=[O:25])[C:24]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:8]=1

Participants

3

Reactant 2

HCID 3776IsopropanolHCID 178429562HCID 178429562, compound

Product 1

HCID 178484949HCID 178484949, compoundYield 41%

Procedure

0.44 g (1.54 mmol) of 6-[2-(3-aminopropyl)-1H-benzimidazol-5-yl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone and 0.43 g (1.71 mmol) of N1 -benzyl-N2 -cyano-0-phenyl-isourea are boiled under reflux in 20 ml of isopropanol for 4 hours. The solid obtained after cooling of the solution to room temperature is suction filtered and recrystallized from methanol. 0.28 g (41%) of colorless crystals melting at 270° C. are obtained.

Workup

  1. customThe solid obtained
  2. filtrationfiltered
  3. customrecrystallized from methanol

Sources & evidence

ORD record
ord-b899bc6d87c64d5ca23e78060919d6ef
Source dataset
uspto-grants-1991_08
Patent number
US05039675

Reaction notes

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