Hydrazine hydrate (1:1) → HCID 178510943, compound

Participants

Reaction Steps

Prepared by a method analogous to that of Example 1d) from 3.3 g (8.2 mmol) of 6-[2-(3-phthalimidopropyl)-1H-benzimidazol-5-yl]-4,5-dihydro-3(2H)-pyridazinone and 2.0 ml (41.1 mmol) of hydrazine hydrate. 0.77 g (35%) of a colorless solid melting at 247° to 249° C. (decomp.) are obtained after chromatographic purification on silica gel with methanol/conc. ammonia (95:5) as solvent, concentration of the main fraction by evaporation under vacuum and crystallization of the residue from ethanol.

Provenance & Evidence