Hydrazine hydrate (1:1) → HCID 178510943, compound

HRID 2248275Notes

Reaction equation

HRID 2248275 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][C:9]2[NH:13][C:12]3[CH:14]=[CH:15][C:16]([C:18]4[CH2:19][CH2:20][C:21](=[O:24])[NH:22][N:23]=4)=[CH:17][C:11]=3[N:10]=2)C(=O)C2=CC=CC=C12.O.NN>>[NH2:5][CH2:6][CH2:7][CH2:8][C:9]1[NH:13][C:12]2[CH:14]=[CH:15][C:16]([C:18]3[CH2:19][CH2:20][C:21](=[O:24])[NH:22][N:23]=3)=[CH:17][C:11]=2[N:10]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178515841HCID 178515841, compound

Product 1

HCID 178510943HCID 178510943, compoundYield 35%

Procedure

Prepared by a method analogous to that of Example 1d) from 3.3 g (8.2 mmol) of 6-[2-(3-phthalimidopropyl)-1H-benzimidazol-5-yl]-4,5-dihydro-3(2H)-pyridazinone and 2.0 ml (41.1 mmol) of hydrazine hydrate. 0.77 g (35%) of a colorless solid melting at 247° to 249° C. (decomp.) are obtained after chromatographic purification on silica gel with methanol/conc. ammonia (95:5) as solvent, concentration of the main fraction by evaporation under vacuum and crystallization of the residue from ethanol.

Sources & evidence

ORD record
ord-5c3f676823114fe6b6ade1f32fb1ca31
Source dataset
uspto-grants-1991_08
Patent number
US05039675

Reaction notes

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