Hydrogen Bromide → HCID 14990687, compound

HRID 2248329Notes

Reaction equation

HRID 2248329 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)O)=[CH:4][C:3]=1[N+:16]([O-:18])=[O:17].[BrH:19]>O>[Br:19][CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([N+:16]([O-:18])=[O:17])[CH:4]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 570414HCID 570414, compound

Product 1

HCID 14990687HCID 14990687, compoundYield 99.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 58 parts of 4-chloro-3-nitro-α-phenylbenzenemethanol and 450 parts of a hydrobromic acid solution 48% in water was stirred for 45 minutes at reflux temperature. After cooling, the product was extracted with dichloromethane. The extract was dried, filtered and evaporated, yielding 71.4 parts (99.3%) of 4-(bromophenylmethyl)-1-chloro-2-nitrobenzene as a residue (int. 132).

Workup

  1. temperatureat reflux temperature
  2. temperatureAfter cooling
  3. extractionthe product was extracted with dichloromethane
  4. customThe extract was dried
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-be4fa59bdd8844528767cae690208bd9
Source dataset
uspto-grants-1991_08
Patent number
US05039677

Reaction notes

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