Hydrochloric Acid → HCID 15097173, compound

HRID 2248351Notes

Reaction equation

HRID 2248351 reaction equation
[N:1]1([CH2:6][C:7]2[CH:8]=[CH:9][C:10]3[N:14]=[N:13][N:12]([O:15][CH2:16][CH2:17][CH2:18][C:19]([O:21]CC)=[O:20])[C:11]=3[CH:24]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[OH-].[Na+].Cl>C(O)C>[N:1]1([CH2:6][C:7]2[CH:8]=[CH:9][C:10]3[N:14]=[N:13][N:12]([O:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[C:11]=3[CH:24]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14990977HCID 14990977, compound

Product 1

HCID 15097173HCID 15097173, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3.2 parts of ethyl 4-[[6-(1H-imidazol-1-ylmethyl)-1H-benzotriazol-1-yl]oxy]butanoate, 25 parts of a sodium hydroxide solution 1N and 20 parts of ethanol was stirred for 1.5 hours at room temperature. 25 Parts of a hydrochloric acid solution 1N were added and the whole was concentrated to a volume of about 20 parts. The precipitated product, which was formed during concentration, was filtered off, washed with water, 2-propanol and 1,1'-oxybisethane and dried, yielding 2.1 parts (71%) of 4-[[6-(1H-imidazol-1-ylmethyl)-1H-benzotriazol-1-yl]oxy]butanoic acid; mp. 170.5° C. (compound 236).

Workup

  1. concentrationthe whole was concentrated to a volume of about 20 parts
  2. customThe precipitated product, which was formed during concentration
  3. filtrationwas filtered off
  4. washwashed with water, 2-propanol and 1,1'-oxybisethane
  5. customdried

Sources & evidence

ORD record
ord-75a4982645ca403dafaf5fb2ebdfd811
Source dataset
uspto-grants-1991_08
Patent number
US05039677

Reaction notes

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