Hydrogen Sulfide → HCID 14579136, compound

HRID 2248359Notes

Reaction equation

HRID 2248359 reaction equation
[SH2:1].C(O)C.[C:5]([CH:7]([C:17]1[O:18][CH:19]=[CH:20][CH:21]=1)[NH:8][C:9]([C:11]1[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=1)=[O:10])#[N:6]>C(N(CC)CC)C>[O:18]1[CH:19]=[CH:20][CH:21]=[C:17]1[CH:7]([C:5](=[S:1])[NH2:6])[NH:8][C:9]([C:11]1[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=1)=[O:10]

Participants

5

Reactant 3

HCID 402Hydrogen SulfideHCID 702EthanolHCID 14579134HCID 14579134, compound

Product 1

HCID 14579136HCID 14579136, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Hydrogen sulfide was blown into an ethanol solution containing 1.4 g of the N-(cyano-2-furanylmethyl)-1-methyl-1H-pyrazol-4-carboxamide as obtained in the above process and 0.7 g of triethylamine, for 1 hour, and the whole was stirred for 1 hour under cooling with ice and then for a further 2 hours at room temperature. Afterwards, the crystal formed was taken out by filtration, washed with chloroform and then dried, to obtain 1.1 g of the intended N-[2-furanyl(thiocarbamoyl)-methyl]-1-methyl-1H-pyrazole-4-carboxamide.

Workup

  1. temperatureunder cooling with ice
  2. waitfor a further 2 hours at room temperature
  3. customAfterwards, the crystal formed
  4. filtrationwas taken out by filtration
  5. washwashed with chloroform
  6. customdried

Sources & evidence

ORD record
ord-c5dab063652b48cb84501c45d28f7ab9
Source dataset
uspto-grants-1991_08
Patent number
US05039694

Reaction notes

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