Acetic Acid → Methyl 1H-imidazole-2-carboxylate

HRID 2248382Notes

Reaction equation

HRID 2248382 reaction equation
C([N:20]1[CH:24]=[CH:23][N:22]=[C:21]1[C:25]([O:27][CH3:28])=[O:26])(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C(O)(=O)C>CO>[C:25]([C:21]1[NH:20][CH:24]=[CH:23][N:22]=1)([O:27][CH3:28])=[O:26]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 13655992HCID 13655992, compound

Product 1

HCID 549395Methyl 1H-imidazole-2-carboxylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

After a solution of 3.2 g (8.7 mmol.) of 1-trityl-2-carbomethoxyimidazole in 40 mL of a 5% solution of acetic acid in methanol was refluxed for 30 minutes, it was concentrated in vacuo. Recrystallization from ethanol afforded colorless needles, mp 187°-188° C.

Workup

  1. concentrationit was concentrated in vacuo
  2. customRecrystallization from ethanol afforded colorless needles, mp 187°-188° C.

Sources & evidence

ORD record
ord-3f70f74d51184acb8a75322580ecc016
Source dataset
uspto-grants-1991_08
Patent number
US05039691

Reaction notes

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